• Medium chain triglycerides are easily converted to

  2018-11-06

  

  Medium chain triglycerides are easily converted to ketone bodies. A study assessing the effects of ketosis induced by the administration of medium chain triglycerides was performed in aged dogs, a natural model of amyloidosis [59]. The dogs received a 2g/kg/day dose of medium chain triglycerides for

• Introduction Botulinum neurotoxins BoNTs composed of seven b

  2018-11-06

  

  Introduction Botulinum neurotoxins (BoNTs), composed of seven biochemically distinct serotypes (BoNT/A–G) secreted by leukotriene bacteria Clostridium botulinum, are extremely potent inhibitors of neurotransmitter exocytosis at neuromuscular junctions (Neale et al., 1999; Rossetto et al., 2006; Mo

• One of the main obstacles in human studies is sample

  2018-11-06

  

  One of the main obstacles in human studies is sample acquisition. Human iPSC lines are usually produced from fibroblasts isolated from skin biopsies, a traumatic invasive procedure demanding local anesthesia and medical follow-up. Hair follicle (HF) plucking, however, is simple, painless and non-inv

• br Results br Discussion In

  2018-11-06

  

  Results Discussion In our present study we compared the cellular properties of engineered MSCs and naïve MSCs. Several lines of evidence indicate for an absence of significant clonal dominance drift that could potentially have occurred in genetically engineered MSCs during the expansion in vit

• A paradoxical outcome of dietary SPI exposure

  2018-11-06

  

  A paradoxical outcome of dietary SPI exposure is the shorter latency of Wnt1-generated mammary tumors, despite the significant reduction in tumor incidence in SPI-fed mice. We previously reported that in female rats exposed to SPI and administered with the direct acting carcinogen N-methyl-nitrosour

• KRAB associated protein KAP also

  2018-11-06

  

  KRAB-associated protein 1 (KAP1, also known as TRIM28 and TIF1β) is a novel Oct3/4-dependent transcription factor that regulates pluripotency (Seki et al., 2010). KAP1 was initially identified as an interaction partner of KRAB-domain containing zinc finger transcription factors (Friedman et al., 199

• br Results br Discussion Graft failure and rejection

  2018-11-06

  

  Results Discussion Graft failure and rejection for patients with acquired SAA remains as one of the important and life-threatening complications, especially in haplo-HSCT (Wagner et al., 1996; Passweg et al., 2006). The EBMT showed that for patients receiving HLA-identical sibling grafts, the

• Thirdly we can report that La induced

  2018-11-06

  

  Thirdly we can report that La-induced effects are ROS-dependent and can therefore be reversed by the addition of antioxidants such as AA, NAc, and LA. Although no data is available on the effects of La on C2C12 differentiation, numerous studies exist elucidating the question how ROS influence this p

• Our data strongly and logically suggest a decreased self ren

  2018-11-06

  

  Our data strongly and logically suggest a decreased self-renewal potential in Ptp4a3-KO tumor-initiating UMI-77 Supplier and, in consequence, an inability to form secondary tumors in vivo. The process of tumorigenesis after carcinogen treatment is exceedingly complex and undoubtedly includes the rol

• AR is present in the nucleus of most

  2018-11-06

  

  AR is present in the nucleus of most epithelial and stromal ezh2 inhibitor of the intact adult prostate. Luminal cells are predominantly, if not exclusively, androgen positive whereas only half of all basal cells are (Wang et al., 2009). AR in the stroma mediates paracrine stimulation of epithelial

• br Introduction Foundational cell fate reprogramming studies

  2018-11-06

  

  Introduction Foundational cell fate reprogramming studies revealed ectopic expression of pluripotency-associated transcription factors (TF) OCT4, SOX2, KLF4, and c-MYC (OSKM) or OCT4, SOX2, NANOG, LIN28 (OSNL) in human fibroblasts (hFibs) cultured in pluripotent supportive conditions was sufficie

• Interferons are a diverse family of cytokines

  2018-11-06

  

  Interferons are a diverse family of cytokines which possess antiviral and immunomodulatory properties (Isaacs and Lindenmann, 1957; Stark et al., 1998; Theofilopoulos et al., 2005). These specialized proteins are produced by cells in response to viral infection. Cellular sensors such as retinoic Wnt

• br Results br Discussion The clinical success of

  2018-11-06

  

  Results Discussion The clinical success of haematopoietic stem/progenitor cell (HSPC) therapy for large bowel disorders is poor, partly due to their limited recruitment following systemic administration. However, cellular therapy may be made effective if systemically transplanted Ramelteon ar

• hUC cells expressed pluripotent markers OCT NANOG KLF and

  2018-11-06

  

  hUC AV-951 expressed pluripotent markers, OCT4, NANOG, KLF4 and SOX2, but expression levels of all, except KLF4 were significantly lower than human ESCs (Fig. S3). Nevertheless, our results were in agreement with a previous report showing expression of pluripotency markers in cells from peri-natal

• The karyotype of the MPSII iPSC

  2018-11-06

  

  The karyotype of the MPSII-2.5 iPSC line was determined by Giemsa-banding, proving normal trametinib 46, XY karyotype, without any detectable abnormalities (Fig. 1B). Materials and methods Acknowledgement We would like to thank the Department of Pediatrics, University of Pécs (Hungary) for c

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