• The COMT gene maps to chromosome q

  2019-07-02

  

  The COMT gene maps to chromosome 22q11.2 (Grossman et al., 1992) and has two protein isoforms. The differences between S-COMT and longer MB-COMT are in the N-termini, which use alternative translation initiation sites and promoters. These two isoforms display different affinity and capacity for COMT

• We can think of two ways in which

  2019-07-02

  

  We can think of two ways in which collagen binding could activate DDR (Figure 8). A single collagen triple helix could interact with both DS domains in the DDR dimer (“composite binding site”) and thereby activate the receptor, similar to the situation exemplified by the growth hormone-growth hormon

• Interestingly our analyses of human PBMCs

  2019-07-02

  

  Interestingly, our analyses of human PBMCs using a monoclonal antibody against EBI2 showed that the expression pattern of human EBI2 is largely overlapping with that in mice. Especially Th17 ABT737 showed homogeneous high expression of EBI2 compared with Th1 cells, which contained a fraction of cel

• reverse transcriptase Introduction Since the recognition of

  2019-07-02

  

  Introduction Since the recognition of AIDS in 1981 more than thirty-five years ago, nearly 70 million individuals have been infected with human immunodeficiency virus type 1 (HIV) and roughly half have died (http://www.unaids.org/en/resources/documents/2016/AIDS-by-the-numbers). Although the introd

• Gene chip is a detection technique that can detect all

  2019-07-02

  

  Gene chip is a detection technique that can detect all the time-point differentially expressed genes (DEGs) information within the same sample. However, due to sample heterogeneity or different sequencing platform, the results for the expressed mRNAs are inconsistent with different gene profile. The

• With respect to the muscle

  2019-07-02

  

  With respect to the muscle compartment, only low protein expression of ASB9 has been detected in healthy human skeletal muscle [as reported in the Human Protein Atlas (HPA)], whereas high levels of Asb5 protein expression are detected in mammalian skeletal muscle, which appears to be important in th

• In contrast to SQLE HMGCR

  2019-07-02

  

  In contrast to SQLE, HMGCR could be efficiently degraded in entacapone lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is consistent with our recentl

• Long QT syndrome LQTS a rare inheritable arrhythmia first de

  2019-07-01

  

  Long QT syndrome (LQTS), a rare inheritable arrhythmia first described by Romano and Ward et al. in the 1960s, is characterized by the prolongation of the QT interval on surface ECGs and an increased risk of potentially fatal ventricular arrhythmias, especially torsade de pointes . In 1995, after ye

• br The indications for ICD placement

  2019-07-01

  

  The indications for ICD placement for the secondary prevention of sudden cardiac death Some patients with underlying SB 203580 hydrochloride disease and/or LV dysfunction die from tachyarrhythmias even after ICD placement [18]. However, no arrhythmic deaths occurred during the implantation or du

• br Methods br Results br Discussion

  2019-07-01

  

  Methods Results Discussion Conclusion Conflict of interest Introduction Placement of the left ventricular (LV) pacing lead in a tributary of the coronary sinus (CS) is one of the most challenging technical aspects of cardiac resynchronization therapy (CRT) device implantation. Fail

• br Discussion In this case report

  2019-07-01

  

  Discussion In this case report, we demonstrated the consistent fusion of P-waves during CS os pacing, except for the last captured beat, which was entrained but not fused, thereby satisfying the entrainment criteria [2,3]. The tachycardia could be induced with reproducible results by a single atr

• Curative treatments which include surgical resection percuta

  2019-07-01

  

  Curative treatments, which include surgical resection, percutaneous ablation and liver transplantation, were considered as the optimal treatment for patients with very early/early stage HCC by BCLC criteria. Furthermore, advances in liver surgery make the resection of large and/or multifocal HCC pos

• Implementation of contemporary treatment protocols incorpora

  2019-07-01

  

  Implementation of contemporary treatment protocols, incorporating adjuvant chemotherapy, have resulted in an improvement in the prognosis of patients diagnosed with osteosarcoma over the past decades. The overall 5-year survival rate has improved from less than 20% in the 1960s to approximately 60%

• 9-amino Camptothecin Furthermore the difference in the mean

  2019-07-01

  

  Furthermore, the difference in the mean S–A interval between HB capture and non-capture in the 4 patients with conduction pattern 2 or 3 was only 20±4ms (range, 16–27ms), and was shorter than the HV interval after ablation in 3 patients (75%). By contrast, in patients with strictly AV nodal retrogra

• Understanding and defining these miRNA profiles

  2019-07-01

  

  Understanding and defining these miRNA profiles helps to uncover the clinical usefulness of miRNAs. Numerous human clinical trials are currently evaluating miRNA therapeutics during various liver diseases, such as targeting miR-122 during chronic hepatitis C infection. Aside from therapeutics, the d

14987 records 937/1000 page Previous Next First page 上5页 936937938939940 下5页 Last page