• br Glycoengineering br The Omics perspective The publication

  2022-02-11

  

  Glycoengineering The « Omics » perspective The publication of the CHO-K1 genome sequence in 2011, followed by the publication of two Chinese hamster and six CHO cell line genomes in 2013, bring new opportunities in developing and engineering CHO Alamethicin australia for improved glycoprotein

• Trelagliptin To maintain low Glu concentrations in the synap

  2022-02-11

  

  To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino Trelagliptin is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes, and

• The dorsal horn of the spinal cord shows a

  2022-02-11

  

  The dorsal horn of the spinal cord shows a high density of Ca2+-permeable AMPA receptors, particularly in the superficial spinal laminae (laminae I and II), where primary afferents carrying nociceptive and thermoreceptive inputs terminate and synapse on spinal second-order neurons (Engelman et al.,

• Up to now the research about the effect of

  2022-02-11

  

  Up to now, the research about the effect of PAs on inhibiting carbohydrase activity in vitro or reducing blood sugar level in vivo was mainly reported in PAs from grape seeds, Lepisanthes alata (Malay cherry) leaves, sorghum, pomegranate, cranberry and persimmon (Banerji and Banerjee, 2016, Barrett

• Although most of the incretin effects on glucose metabolism

  2022-02-11

  

  Although most of the incretin effects on wst-1 assay metabolism can be secondary to their action on insulin/glucagon secretion, some evidence strongly suggests that they could also act directly on liver glucose utilization and production [4], [13], [22], [27], [34], [44]. Supporting this concept, A

• br Methods br Results br Discussion The

  2022-02-11

  

  Methods Results Discussion The measurement of intraocular pressure was made with a commercially available rebound tonometer, the Tonovet®. In our studies, Tonovet® underestimated the intraocular pressure in both animal models, being this effect more pronounced in the rat. To study the effe

• uPAR another newly discovered ligand

  2022-02-10

  

  uPAR, another newly discovered ligand, has implicated FPRL1 as a potential link between the fibrinolytic cascade and inflammation. uPA is a serine protease best known for its ability to regulate fibrinolysis and for its importance in tissue remodeling and tumor invasion [49]. However, uPA also induc

• It has been reported that the FDP synthase

  2022-02-10

  

  It has been reported that the FDP synthase in Hevea latex has a major role to produce the starter substrate FPP for the prenyl chain elongation in natural rubber biosynthesis (Takaya et al., 2003). Accumulation of HbFDP mRNA transcripts in different tissue types including latex (natural rubber) prod

• The proposed contributory role of

  2022-02-10

  

  The proposed contributory role of endogenous histamine via activation of H1 receptor in the locomotor sensitization induced by caffeine was further ratified by H1 receptor antagonism during the induction phase and subsequently its effect on expression to locomotor sensitization induced by caffeine.

• Oltipraz has been shown to

  2022-02-10

  

  Oltipraz has been shown to inhibit the growth of HCC Phosphoramidon Disodium Salt and is being evaluated in clinical trials as a potential anti-cancer drug for HCC (Mann et al., 2009; Piton et al., 2005; Yates and Kensler, 2007). The present observation that pre-treatment of tumorigenic liver cells

• Ruxolitinib phosphate Over the last years numerous studies g

  2022-02-10

  

  Over the last 15 years, numerous studies gave insights into sGC activation and binding of activators: Photoaffinity labelling studies with cinaciguat suggested the N-terminus of the β1 subunit as target region for this new drug [17]. Schmidt et al. identified the amino acids tyrosine 135, serine 137

• br Conflict of Interest Both GM and BDH are shareholders

  2022-02-10

  

  Conflict of Interest Both GM and BDH are shareholders in Caldan Therapeutics, a company exploring potential novel treatments for type 2 diabetes. Acknowledgments Work described herein was supported by Biotechnology and Biological Sciences Research Council [grant BB/K019864/1)] (to GM) and [gr

• br Endogenous lipids as SLC transporter modulators Lipids co

  2022-02-10

  

  Endogenous lipids as SLC6 transporter modulators Lipids constitute part of the environment in which membrane-embedded transporters operate [62]. Endogenous lipids can act as inhibitory ligands [63] or functionally important components of the membrane that impart changes in transporter structure [

• All of the abovementioned effects of PUFAs signal their

  2022-02-09

  

  All of the abovementioned effects of PUFAs signal their involvement in a cellular phenotype switching phenomenon, which is increasingly recognized as a potential target for future pharmacotherapies of atherosclerosis, especially for individuals who do not respond to the classical lipid-lowering stra

• br Materials and methods br Results and discussion

  2022-02-09

  

  Materials and methods Results and discussion Conclusions Acknowledgments The authors are grateful to Dr. N. Prevete for providing the human AGS shCTR and AGS shFPR2 cells. This work was supported by POR Campania FSE 2007-2013 Project CREME and Ministry of Health, Italy, RF-2011-02349269.

15750 records 480/1050 page Previous Next First page 上5页 476477478479480 下5页 Last page