• The membrane metalloendopeptidase MME gene

  2022-04-18

  

  The membrane metalloendopeptidase (MME) gene is located at human chromosome 3q21-27. It encodes a 100-kD type II transmembrane glycoprotein, a widely expressed membrane metalloendopeptidase that degrades a number of substrates. The active site of the enzyme faces the extracellular space. MME is wide

• ac 723 br Retrieval requires histamine H receptors in dorsal

  2022-04-16

  

  Retrieval requires histamine H1 receptors in dorsal hippocampus Retrieval is a dynamic process that requires neurotransmitter regulation (Barros et al., 2000, Barros et al., 2001). Recently, histamine, and histaminergic transmission has entered the list of putative neurotransmitter modulators of

• Sometime ago we have described diamino triazines as histamin

  2022-04-16

  

  Sometime ago we have described diamino-1,3,5-triazines as histamine H4R ligands,12, 13 and aryl derivatives of the 1,3,5-triazine, which attenuated inflammatory and nociceptive response in vivo in the rodent models of inflammation induced by ZD 7288 and zymosan. In this work we describe new derivat

• br Dynamic Localization of Hippo Pathway Components The obse

  2022-04-16

  

  Dynamic Localization of Hippo Pathway Components The observation that Wts normally localizes with an inhibitor, Jub, raised the question of how and where Wts normally becomes activated. Under conditions of pathway activation in Drosophila imaginal discs, Wts relocalized from Jub to Ex, where it i

• br Conflict of interest br Funding This work

  2022-04-16

  

  Conflict of interest Funding This work was supported by the National Institutes of Health MSK Cancer Center Support Grant/Core Grant [P30 CA008748]. The funding source had no involvement in the study design; in the collection, analysis and interpretation of data; in the writing of the report;

• The HCV NS A protease consists of two

  2022-04-16

  

  The HCV NS3/4A protease consists of two subunits, NS3 and NS4A. NS3 comprises an N-terminal serine protease domain and a C-terminal RNA helicase domain [12]. NS4A acts as a cofactor, which ties the holoenzyme complex to an intracellular membrane compartment. The presence of the central region of NS4

• br STAR Methods br Acknowledgments We thank Prof Y

  2022-04-16

  

  STAR★Methods Acknowledgments We thank Prof. Y. Tomari at the University of Tokyo for experimental advice and K. Hanada for technical assistance. This research was supported by Grants-in-Aid for Scientific Research on Innovative Areas “Nascent Chain Biology” (JP15H01548 and JP17H05677 to T.I. a

• br Activity dependent control of

  2022-04-16

  

  Activity-dependent control of myelination and myelin maintenance Oligodendrocytes have intrinsic myelinating capacity and can myelinate fixed SU5416 in addition to synthetic nanofibers and micropillars [21, 34, 35]. What prevents oligodendrocytes from myelinating dendrites or other cells in the

• br Conclusion br Acknowledgements This work

  2022-04-16

  

  Conclusion Acknowledgements This work was supported by a Grant-in-Aid for challenging Exploratory Research (15K12715) and was a partly supported by Suzuken Memorial Foundation (2014). The authors would like to thank Enago (www.enago.jp) for the English language review. G protein-coupled rec

• br Discussion Naloxone and CTAP were able

  2022-04-16

  

  Discussion Naloxone and CTAP were able to alter the febrile response induced by gp120. This effect was particularly evident during the initial hours following gp120 administration (90–210min). We also investigated the potential role of the delta-2 opioid receptor in gp120-induced fever. The delta

• 2-MeOE2 Materials and methods Standard curve

  2022-04-16

  

  Materials and methods Standard curve for methylglyoxal. Different concentrations (10, 25, 50, and 100μM) of pure MG (Sigma) were derivatized with 1,2-diaminobenzene and the absorbance of the resulting derivative was read by Cary 50 Bio UV-Visible spectrophotometer (Varian). One milliliter of total

• In three groups independently proposed two different mechani

  2022-04-16

  

  In 2001, three groups independently proposed two different mechanisms for the catalytic reaction of GlxI [5], [6], [7]. Richter and Krauss (RK) used HF/4–31G calculations of the active site, coupled with a frozen effective fragment potential description [8], [9] of eleven residues in the binding sit

• We next compared the enhancing effects of nM

  2022-04-16

  

  We next compared the enhancing effects of 100nM zinc on currents produced by a low concentration of glycine with zinc effects on the same currents produced by the partial agonist taurine. In this experiment, zinc was co-applied with concentrations of glycine or taurine producing 5–10% of the maximal

• It was previously proposed that glucagon acts in the liver

  2022-04-15

  

  It was previously proposed that glucagon acts in the liver, in which a signal is produced and relayed to the pituitary adenylate cyclase-activating peptide via vagal nerves [8], [36], [37]. The concept that the liver is the primary target site was supported by the studies reporting that the glucago

• It is generally considered that elevated blood glucose due t

  2022-04-15

  

  It is generally considered that elevated blood glucose due to insulin resistance is an important factor in islet compensation to high fat feeding [27]. However, we have shown recently that insulin resistance induced in mice by hydrocortisone injection provokes significant islet Curcumin receptor in

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