• A number of lines of evidence

  2018-10-23

  

  A number of lines of evidence has suggested BARD1 as a tumor suppressor (Irminger-Finger and Jefford, 2006; Irminger-Finger et al., 2016). BRCA1-BARD1 heterodimer plays a crucial role in homologous repair in response to DNA damage (Stark et al., 2004). The knockout of Bard1 is lethal in mouse (McCar

• On the basis of the available experimental

  2018-10-23

  

  On the basis of the available experimental data, we hypothesised that KLF15gene variants are associated with LV mass in man. The KLF15 gene is located on chromosome 3q21-q22 and comprises of 3 exons spanning over 14.8kb of genomic DNA transcribed into a 416 amino pim kinase inhibitor protein. Two SN

• purinergic receptors Since p is reported to be a critical co

  2018-10-23

  

  Since p53 is reported to be a critical component in autophagy pathways, we studied the role of p53 in fluvastatin-induced autophagy. We found that fluvastatin induced total p53 expression in a dose and time dependent manner (Fig. 4A). Further study showed fluvastatin did not significantly increase t

• The decrease in blood oxygen saturation

  2018-10-23

  

  The decrease in blood oxygen saturation correlates with increased plasma EPO levels in Slc40a1C326S/C326S mice. Hypoxia is the main physiological inducer of EPO production in the kidney via the hypoxia inducible factor HIF2α/HIF1β heterodimer (Haase, 2010). In Slc40a1C326S/C326S mice iron may also d

• It is known that evidence generated from small sample

  2018-10-23

  

  It is known that evidence generated from small sample sizes is especially prone to error: both false negatives due to inadequate power and false positives due to biased samples (Button et al., 2013). Meta- and mega-analysis of VBM studies combining data from independent studies can substantially imp

• br Results br Discussion For any new technology a primary

  2018-10-23

  

  Results Discussion For any new technology a primary concern is safety and reactogenicity, especially for a vaccine that potentially contains powerful stimulators of the innate immune system. In these studies, we saw a correlation between dose and local reactions, but even at the highest dose o

• NAbs occurring after initial infection with HIV are generall

  2018-10-23

  

  NAbs occurring after initial infection with HIV-1 are generally not associated with any clinical or biological benefits. Doria-Rose et al. (2010) suggested that the limited breadth of neutralization observed in whole-serum samples from LTNP patients maybe attributable to low levels of antigenic stim

• Invivo Hx depletion in mouse models of

  2018-10-23

  

  Invivo, Hx depletion in mouse models of hemolytic disorders, β-thalassemic mice and phenylhydrazine (PHZ)-treated mice, was associated with heme accumulation and oxidative stress in the heart. Data show that in β-thalassemic mice, low Hx serum level, was associated to increased expression of heme- a

• Como hab amos afirmado previamente

  2018-10-22

  

  Como habíamos afirmado previamente, los espacios en la obra de Eltit son múltiples, cambiantes, movibles y alegóricos, y comprenden principalmente lugares abiertos que no se configuran de forma homogénea, sino por medio de matices. Para Brito (2014), el espacio en la obra de Eltit es un escenario do

• Organization This paper is organized as follows Section disc

  2018-10-22

  

  Organization. This paper is organized as follows: Section 2 discusses related work. In Section 3, background and definitions of data quality concepts are presented. Then, Section 4 highlights data cleaning in medical applications. Section 5 presents the proposed ICCFD_Miner, MICCFD_Miner, and T_Repa

• br Conceptual model building The conceptual model for

  2018-10-22

  

  Conceptual model building The conceptual model for this study is built on the theoretical grounding of Social Network theory, Trust Transfer theory, and Task-Technology Fit theory. Extensive review of the literature resulted in the identification of six constructs i.e. informational support, SCR7

• Especially the dry and wet bulb temperature of the exterior

  2018-10-22

  

  Especially the dry and wet bulb temperature of the exterior climate and the global radiation (see Figure 2) are relevant to the dimension of the HVAC systems. In summary, it can be concluded that the temperature level of the outdoor climate does not require any heating during the whole year while ai

• br Methodology Basic indicators for evaluating the

  2018-10-22

  

  Methodology Basic indicators for evaluating the blast-resistant architectural spaces were identified in this study using library resources. The proposed indices were extracted from interviews with experts in the field of architecture and explosives (Table 1). A questionnaire was presented to 15 e

• The most significant characteristic of active learning is st

  2018-10-22

  

  The most significant characteristic of active learning is student involvement: students are actively engaged in individual or group activities during the class session, these may include reading, discussing, commenting, and exploring tasks, ideas and theories (Liebman, 1997). Rather than declamatory

• By the end of World War II Alberto Pirelli

  2018-10-22

  

  By the end of World War II, Alberto Pirelli ordered the construction of a modern skyscraper in an area near the main train station in Milan. This building would serve as a corporate symbol of his family׳s rubber company. Immediately, the building became the symbol of the new postwar city and of the

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